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KMID : 0605720160220020101
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Journal of the Korean Society of Biological Therapies in Psychiatry
2016 Volume.22 No. 2 p.101 ~ p.107
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Stress Response in Chronic Unpredictable Stress Animal Model
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Seo Min-Soo
Kang Kyung-Ku
Kim Choong-Yong
Woo Jung-Min
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Abstract
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Objectives：The aim of this study is evaluating the biomarkers such as stress-related hormones(Cortisol, Corticosterone, Dehydroepiandrosterone ; DHEA) in chronic unpredictable stress animal model.
Methods：The animal were stressed by 6 different unpredictable protocols during 28 days, in terms of chronic unpredictable stress model. We measured stress responses of the rat by recording weight gain rate, behavior test(y-maze test, open field activity test), ELISA(enzyme-linked immunosorbent assay) assay of stress-related hormones(Cortisol, Corticosterone, DHEA).
Results：Stress group showed lower weight gain rate compared to control group. Open field activity were increased in stress group, so that is related increasing of anxiety in stress group. Serum cortisol and DHEA level were increased in stress group. But corticosterone level was decreased in stress group.
Conclusion：These findings suggest that serum DHEA level may have potential for chronic stress diagnosis and correlation of stress-related hormone present as biomarker for diagnosis of various stress.
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KEYWORD
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Stress, Chronic unpredictable stress model, DHEA, Cortisol, Corticosterone
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